The recommended dose is 160 mg enzalutamide (four 40 mg capsules) as a single oral daily dose.Medical castration with a luteinising hormone-releasing hormone (LHRH) analogue should becontinued during treatment of patients not surgically castrated.If a patient misses taking Xtandi at the usual time, the prescribed dose should be taken as close aspossible to the usual time. If a patient misses a dose for a whole day, treatment should be resumed thefollowing day with the usual daily dose.If a patient experiences a ≥ Grade 3 toxicity or an intolerable adverse reaction, dosing should bewithheld for one week or until symptoms improve to ≤ Grade 2, then resumed at the same or a reduceddose (120 mg or 80 mg) if warranted.
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